Elliot Melendez, MD

2014 DICP Faculty Fellowship Recipient

ELLIOTT MELENDEZ, MD,Director, Critical Care Safety and Quality, All Children's Hospital, St. Petersburg, Florida, a Johns Hopkins Hospital

Mentor: Richard Bachur, MD, Senior Associate in Medicine, Associate Professor of Pediatrics; Harvard Medical School, Chief of the Division of Emergency Medicine, Boston Children’s Hospital

Department Chair: Michael SD Agus, MD, Associate Professor of Pediatrics, Harvard Medical School; Division Chief, Medicine Critical Care, Department of Medicine; Medical Director, Medicine Intensive Care Unit and Intermediate Care Program, Boston Children’s Hospital

Project Title: Association of cytopenia and endothelial dysfunction in children with severe sepsis and septic shock, and Vascular Endothelial Growth Factor (VEGF) and soluble VEGF receptor-1 (sFLT1) as Novel Biomarkers for worse outcomes in children with Severe Sepsis and Septic Shock

Project Description:

The primary aim of this study is to assess the correlation between cytopenia, VEGF and sFLT1 as predictors of poor outcomes for children with severe sepsis and sepsis shock (SS) as compared to children with isolated sepsis. Children who present to the emergency department with SS and sepsis will be enrolled in study. Leftover blood from routine analysis obtained within the emergency department will be collected after informed consent and analyzed for the presence of VEGF and sFLT1 and cytopenia. The results will be compared as to children with SS have worse cytopenia and higher levels of these biomarkers. In addition, in children with SS, a correlation analysis will be performed to assess if higher levels are predictive of worse outcomes. Finally, the rate of change of biomarkers over the course of their hospital stay will be analyzed to assess for outcome differenced based on change from presentation.


Dr. Meléndez, a graduate of Harvard Medical School (HMS) class of 1999, is a critical care physician at JOhns Hopkins All Children's Hospital, St. Petersburg, FL.   Despite dropping out of high school in the Bronx, he went on to attend Lehman College - City University of New York and then HMS, graduating cum laude from both institutions. Dr. Meléndez completed his general pediatrics training at Boston Children's Hospital, and was the first person to complete subspecialty fellowships in Pediatric Critical Care at Massachusetts General Hospital and Pediatric Emergency Medicine at Boston Children's Hospital. He previously provided care to children through the Division of Emergency Medicine and the Division of Medicine Critical Care at Boston Children’s Hospital where he also served as the associate director of quality and safety in the Division of Medicine Critical Care at BCH.

He is active in clinical research and quality improvement in children presenting with severe sepsis and shock, and is a member of a national collaborative to improve sepsis management. His academic work revolves around the study of specific biomarkers in sepsis to assist in prognosticating outcomes. He is also a member of the Diversity and Cultural Competency Council, and as a result co-chairs a subcommittee addressing respectful interactions as they pertain to the diverse community of BCH. He has been honored for his role in teaching, receiving the prestigious Children’s Hospital Charles A. Janeway Award for best faculty educator in 2010, selected among greater than 1000 faculty. Finally, Dr. Melendez has also been recognized for his mentoring of underrepresented minorities in medicine and inner city high school and college students by receiving the HMS Michael Shannon mentoring award.