Aaron Kyle Styer, MD

2011 DICP Faculty Fellowship Alumni

AARON KYLE STYER, MD, Associate Professor of Obstetrics, Gynecology and Reproductive Biology 

Mentor: Bo Rueda, PhD, Associate Professor of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School and Massachusetts General Hospital

Department Chair: Isaac Schiff, MD, Joe Vincent Meigs Professor of Gynecology, Harvard Medical School; Head of the Department of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital

Project Title: "Defining the Utility of MicroRNA Expression Profiles to Predict Ethnic Differences in the Clinical Presentation of Uterine Fibroids"

Project Description:

Uterine fibroids (leiomyomata), the most common benign neoplasms of women, are the leading indication for hysterectomy in the United States. Leiomyomata have a disproportionately higher incidence in African-American women, result in significant morbidity during reproductive years, and are more likely to necessitate surgical therapy due to more advanced stage at presentation. Unfortunately, the underlying mechanisms of development, recurrence, and ethnic specific symptoms are not well understood. Given our current inability to render consistently effective medical treatment, predict the severity of disease, or determine which women will develop this disorder, it is crucial to elucidate the underlying mechanisms of this condition. The disproportionate affliction of this disorder in African American women affords a prime opportunity to characterize novel genetic factors which influence how this disease presents clinically in specific patient populations. The promising technology of microRNA (miRNA) has recently emerged as a potential noninvasive biomarker for a diverse array of human diseases. As in other disorders, differing degrees of disease severity may be suggestive of altered genetic regulation and differential miRNA expression. During a 24-month period, serum and leiomyomata obtained from patients undergoing either myomectomy or hysterectomy for symptomatic fibroids will be used for miRNA analysis, examined for ethnic specific genetic signatures, and correlated to demographic factors and clinical presentation. With further development, miRNA may provide the means to significantly improve the diagnosis, treatment, and surveillance of uterine leiomyomata, and expand our understanding of the impact of ethnic specific miRNA expression on clinical outcome.


Dr. Aaron K. Styer is a reproductive endocrinologist, founding partner, and co-medical director of CCRM-Boston. He is board certified in obstetrics and gynecology and the subspecialty, reproductive endocrinology and infertility.

He has been honored with the Most Compassionate Doctor Award, Patient’s Choice Award, and Top Doctor Award by patients and peers. Dr. Styer’s primary goal is to provide compassionate patient-centered care based upon efficient testing, accurate diagnosis, and empathy to the stressors of infertility. He favors a collaborative approach for selecting the most ideal treatment options based upon your unique circumstances. With his clinical expertise, and warm, personable manner, Dr. Styer aims to utilize the latest evidence and technology to optimize and personalize your care.

Dr. Styer received his undergraduate degree in biology from Duke University and his medical degree from Vanderbilt University School of Medicine. He completed residency in the Harvard Integrated Program in Obstetrics and Gynecology at Brigham and Women’s Hospital and Massachusetts General Hospital (MGH). He completed a clinical fellowship in Reproductive Endocrinology and Infertility at MGH/Harvard Medical School. Previously, he practiced at MGH for more than a decade where he was appointed Associate Professor of Obstetrics, Gynecology and Reproductive Biology at Harvard Medical School.

He is active nationally in patient outcomes research, in patient education, and serves on several committees in reproductive medicine which direct national clinical care standards. He is the Vice Chair of Society of Assisted Reproductive Technology Clinical Online Reporting System (SART-CORS) research committee and is an active member of the Task Force of the Practice Committee and Patient Education Committee of the American Society for Reproductive Medicine (ASRM). He is a fellow of The American College of Obstetricians and Gynecologists (ACOG), and a member of the ASRM, Society for Reproductive Endocrinology and Infertility (SREI), and the Society for Reproductive Investigation (SRI). He is also a Clinical Research/Reproductive Endocrinology Scientist (CREST) Scholar, supported by the ASRM and National Institute of Health. Further, he serves as an oral board examiner for the American Board of Obstetrics and Gynecology (ABOG), where he examines physicians seeking board certification in reproductive endocrinology and infertility.

Dr. Styer is nationally recognized for his expertise, research, and invited lectures in elective single embryo transfer, predictors of IVF pregnancy success, ovulation induction, and fertility outcomes in women with uterine fibroids and endometriosis. He has published more than 75 original abstracts, research articles, review articles, invited editorials, and book chapters. He is a reviewer of mainstream peer-reviewed reproductive medicine journals including Fertility and Sterility, Human Reproduction, Journal of Clinical Endocrinology and Metabolism, and The American Journal of Obstetrics and Gynecology, and is an editorial board member of the journal, Reproductive Biology and Endocrinology. Dr. Styer’s published studies are available on PubMed. Additionally, he has been interviewed locally and nationally in the Boston Globe, Boston.com, The New York Times, Newsweek, and Self for topics regarding infertility and endometriosis.

Along with his team, Dr. Styer believes in transparent, interactive dialogue, and pledges to listen to your challenges with infertility and to help ensure future success in building your family.